I shot this photo at ISO 3200, 1/50th of a second, F2.8 on my 50 mm lens. It was pretty dark in the room! Available florescent light about 3 feet away on the right side of the photo. I opened it in Lightroom, color balanced it, hit the noise reduction in Lightroom and output it. Looks pretty good to me! Most point and shoots start to get unusable at anything over ISO 400.
This photo of Peaches and Mary is of a pretty much nightly thing with them.